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pentobarbital will reduce the level or outcome of buprenorphine, very long-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Sufferers who transfer to buprenorphine long-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers need to be monitored to ensure bupreno